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• Mean activities

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• Activity deltas table
• Regulatory interactions
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Motif ID: RXR{A,B,G}.p2

Z-value: 1.701

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_-_2971281	3.073		SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr6_-_2971787	2.877		SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr5_-_172755418	2.576		STC2	stanniocalcin 2
chr6_-_132272311	2.449	NM_001901	CTGF	connective tissue growth factor
chr17_-_76921453	2.397	NM_003255	TIMP2	TIMP metallopeptidase inhibitor 2
chr17_-_76921205	2.393		TIMP2	TIMP metallopeptidase inhibitor 2
chr11_-_86666211	2.392	NM_012193	FZD4	frizzled family receptor 4
chr7_+_116166346	2.089	NM_001172896 NM_001172897	CAV1	caveolin 1, caveolae protein, 22kDa
chr7_-_107643330	1.977	NM_002291	LAMB1	laminin, beta 1
chr5_-_131563481	1.925	NM_001017974 NM_001142598 NM_001142599	P4HA2	prolyl 4-hydroxylase, alpha polypeptide II
chr7_-_94285477	1.716	NM_001099400 NM_001099401 NM_003919	SGCE	sarcoglycan, epsilon
chr21_+_46825001	1.678	NM_130445	COL18A1	collagen, type XVIII, alpha 1
chr5_-_172755195	1.668		STC2	stanniocalcin 2
chr14_-_103988829	1.637		CKB	creatine kinase, brain
chr21_+_46825291	1.633
chr1_-_154946801	1.568		SHC1	SHC (Src homology 2 domain containing) transforming protein 1
chr1_-_154946859	1.554	NM_001130041 NM_001202859 NM_003029	SHC1	SHC (Src homology 2 domain containing) transforming protein 1
chr7_-_94285426	1.478		SGCE	sarcoglycan, epsilon
chr7_-_94285372	1.462		SGCE	sarcoglycan, epsilon
chr3_-_120169493	1.430	NM_007085	FSTL1	follistatin-like 1
chr1_-_154946830	1.407		SHC1	SHC (Src homology 2 domain containing) transforming protein 1
chr9_+_103235489	1.391	NM_003692	TMEFF1	transmembrane protein with EGF-like and two follistatin-like domains 1
chr11_-_2162340	1.346	NM_001127598	IGF2	insulin-like growth factor 2 (somatomedin A)
chr17_-_76921076	1.335		TIMP2	TIMP metallopeptidase inhibitor 2
chr8_+_38854524	1.335		ADAM9	ADAM metallopeptidase domain 9
chr8_+_38854431	1.325	NM_003816	ADAM9	ADAM metallopeptidase domain 9
chr6_-_33266297	1.323		RGL2	ral guanine nucleotide dissociation stimulator-like 2
chr10_-_81205091	1.279	NM_153367	ZCCHC24	zinc finger, CCHC domain containing 24
chrX_-_99891690	1.279	NM_003270	TSPAN6	tetraspanin 6
chr7_-_45960738	1.277	NM_000598 NM_001013398	IGFBP3	insulin-like growth factor binding protein 3
chr15_+_33010174	1.213	NM_001191322 NM_001191323 NM_013372	GREM1	gremlin 1
chr9_+_36036900	1.192	NM_021111	RECK	reversion-inducing-cysteine-rich protein with kazal motifs
chr11_-_65640199	1.172	NM_016938	EFEMP2	EGF containing fibulin-like extracellular matrix protein 2
chr19_-_50143350	1.152	NM_006270	RRAS	related RAS viral (r-ras) oncogene homolog
chr11_+_10326618	1.130	NM_001124	ADM	adrenomedullin
chr15_+_74218794	1.130		LOXL1	lysyl oxidase-like 1
chr6_+_143999058	1.126	NM_001100164 NM_001100165	PHACTR2	phosphatase and actin regulator 2
chr15_+_74218786	1.124	NM_005576	LOXL1	lysyl oxidase-like 1
chr22_-_19511777	1.104		CLDN5	claudin 5
chr7_+_94024201	1.102		COL1A2	collagen, type I, alpha 2
chr5_+_92920592	1.101		NR2F1 NR2F2	nuclear receptor subfamily 2, group F, member 1 nuclear receptor subfamily 2, group F, member 2
chr9_+_137533643	1.090	NM_000093	COL5A1	collagen, type V, alpha 1
chr15_+_74218811	1.083		LOXL1	lysyl oxidase-like 1
chr9_+_103235634	1.065		TMEFF1	transmembrane protein with EGF-like and two follistatin-like domains 1
chr7_+_94023872	1.065	NM_000089	COL1A2	collagen, type I, alpha 2
chrX_-_34675366	1.057	NM_031442	TMEM47	transmembrane protein 47
chr1_-_225840660	1.051	NM_001008493 NM_018212	ENAH	enabled homolog (Drosophila)
chr3_+_133465204	1.043		TF	transferrin
chr3_+_133465250	1.033		TF	transferrin
chr3_-_50360109	1.026	NM_003773 NM_033158	HYAL2	hyaluronoglucosaminidase 2
chr1_-_95392501	1.026	NM_001839	CNN3	calponin 3, acidic
chr17_-_62657997	1.023		SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr3_+_133465098	1.022		TF	transferrin
chr11_+_129939787	1.018		APLP2	amyloid beta (A4) precursor-like protein 2
chr21_-_46707748	1.016	NM_015227 NM_133635	POFUT2	protein O-fucosyltransferase 2
chr17_-_39968450	0.998	NM_006455	LEPREL4	leprecan-like 4
chr19_+_50354368	0.996	NM_017432	PTOV1	prostate tumor overexpressed 1
chr22_+_38201113	0.993	NM_005318	H1F0	H1 histone family, member 0
chr11_+_129939667	0.989	NM_001142276 NM_001142277 NM_001142278 NM_001642	APLP2	amyloid beta (A4) precursor-like protein 2
chr14_-_103989195	0.980	NM_001823	CKB	creatine kinase, brain
chr20_+_11871364	0.951	NM_181443	BTBD3	BTB (POZ) domain containing 3
chr11_+_129939807	0.948		APLP2	amyloid beta (A4) precursor-like protein 2
chr7_+_143078399	0.936		ZYX	zyxin
chr19_+_45349560	0.932		PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_+_43996478	0.928	NM_002840 NM_130440	PTPRF	protein tyrosine phosphatase, receptor type, F
chr6_-_2971981	0.928		SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr4_+_38869346	0.928	NM_138389	FAM114A1	family with sequence similarity 114, member A1
chr3_+_133464883	0.911	NM_001063	TF	transferrin
chrX_-_51239426	0.903	NM_018159	NUDT11	nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr11_+_129939792	0.903		APLP2	amyloid beta (A4) precursor-like protein 2
chr10_+_89419352	0.899	NM_001015880 NM_004670	PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr11_+_129939847	0.891		APLP2	amyloid beta (A4) precursor-like protein 2
chr12_-_54812936	0.887		ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_106641675	0.882	NM_006825	CKAP4	cytoskeleton-associated protein 4
chr14_+_101193275	0.881		DLK1	delta-like 1 homolog (Drosophila)
chr8_+_70405080	0.871		SULF1	sulfatase 1
chr9_-_99329092	0.865	NM_001077181	CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr7_-_124405029	0.864		GPR37	G protein-coupled receptor 37 (endothelin receptor type B-like)
chr13_+_111138079	0.862		COL4A2	collagen, type IV, alpha 2
chr16_+_67571980	0.860		FAM65A	family with sequence similarity 65, member A
chr22_+_38092994	0.856	NM_001039141	TRIOBP	TRIO and F-actin binding protein
chr1_-_59248287	0.856		JUN	jun proto-oncogene
chr1_-_236228382	0.853		NID1	nidogen 1
chr4_+_184020343	0.846	NM_024949	WWC2	WW and C2 domain containing 2
chr17_-_56065474	0.843		VEZF1	vascular endothelial zinc finger 1
chr4_-_80994183	0.829
chr1_+_182992694	0.825
chrX_+_38420690	0.809	NM_004615	TSPAN7	tetraspanin 7
chr17_+_39969200	0.807		FKBP10	FK506 binding protein 10, 65 kDa
chr9_-_16870664	0.796		BNC2	basonuclin 2
chr7_+_143078444	0.793		ZYX	zyxin
chr15_+_39873276	0.792	NM_003246	THBS1	thrombospondin 1
chr8_+_70405027	0.783	NM_001128205 NM_001128206	SULF1	sulfatase 1
chr6_-_128841432	0.772	NM_002844 NM_001135648	PTPRK	protein tyrosine phosphatase, receptor type, K
chr17_-_41174402	0.766		VAT1	vesicle amine transport protein 1 homolog (T. californica)
chr7_+_94138991	0.766	NM_022900	CASD1	CAS1 domain containing 1
chr7_+_94139331	0.759		CASD1	CAS1 domain containing 1
chr6_-_33266735	0.756		RGL2	ral guanine nucleotide dissociation stimulator-like 2
chr11_+_450260	0.753	NM_030783	PTDSS2	phosphatidylserine synthase 2
chr1_+_19972259	0.750	NM_001204086	NBL1	neuroblastoma, suppression of tumorigenicity 1
chr7_+_143078447	0.749		ZYX	zyxin
chr5_-_131562934	0.747	NM_001017973 NM_004199	P4HA2	prolyl 4-hydroxylase, alpha polypeptide II
chr20_-_44539597	0.747	NM_001242921	PLTP	phospholipid transfer protein
chr6_-_33266745	0.746		RGL2	ral guanine nucleotide dissociation stimulator-like 2
chr17_-_41174327	0.744		VAT1	vesicle amine transport protein 1 homolog (T. californica)
chr11_+_450346	0.731		PTDSS2	phosphatidylserine synthase 2
chr3_-_51993955	0.730		PCBP4	poly(rC) binding protein 4
chr5_-_55290601	0.730	NM_001190981 NM_002184 NM_175767	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)
chr8_-_57906376	0.726		IMPAD1	inositol monophosphatase domain containing 1
chr9_-_13279562	0.722		MPDZ	multiple PDZ domain protein
chr17_+_39969205	0.712		FKBP10	FK506 binding protein 10, 65 kDa
chr20_-_44539542	0.712		PLTP	phospholipid transfer protein
chr17_-_41174431	0.710	NM_006373	VAT1	vesicle amine transport protein 1 homolog (T. californica)
chr5_-_87564615	0.706	NM_153354	TMEM161B	transmembrane protein 161B
chr3_-_38691118	0.705	NM_000335 NM_001099404 NM_001099405 NM_198056 NM_001160160 NM_001160161	SCN5A	sodium channel, voltage-gated, type V, alpha subunit
chr19_+_50016435	0.699	NM_004107	FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chrX_-_51239295	0.699		NUDT11	nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr8_-_57906402	0.693		IMPAD1	inositol monophosphatase domain containing 1
chr2_-_202316227	0.683	NM_015049	TRAK2	trafficking protein, kinesin binding 2
chr6_-_116575170	0.682	NM_021648	TSPYL4	TSPY-like 4
chr1_-_33815340	0.677		PHC2	polyhomeotic homolog 2 (Drosophila)
chrX_+_67718868	0.673		YIPF6	Yip1 domain family, member 6
chr7_+_143078608	0.671		ZYX	zyxin
chr12_+_81110689	0.670	NM_005593	MYF5	myogenic factor 5
chr19_+_45349584	0.667		PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr5_+_109025729	0.667		MAN2A1	mannosidase, alpha, class 2A, member 1
chrX_+_135229536	0.667	NM_001159702 NM_001159703 NM_001449	FHL1	four and a half LIM domains 1
chr20_+_53092131	0.661	NM_018431	DOK5	docking protein 5
chr6_-_33266700	0.658		RGL2	ral guanine nucleotide dissociation stimulator-like 2
chr1_-_94702916	0.657		ARHGAP29	Rho GTPase activating protein 29
chr20_+_35169897	0.657		MYL9	myosin, light chain 9, regulatory
chr15_-_90347173	0.654		ANPEP	alanyl (membrane) aminopeptidase
chr1_+_51701995	0.654		RNF11	ring finger protein 11
chr19_+_50016500	0.652		FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chr17_+_39968961	0.651	NM_021939	FKBP10	FK506 binding protein 10, 65 kDa
chr19_+_50354417	0.650		PTOV1	prostate tumor overexpressed 1
chrX_-_119603136	0.650		LAMP2	lysosomal-associated membrane protein 2
chr12_+_52345437	0.648	NM_004302 NM_020328	ACVR1B	activin A receptor, type IB
chr20_+_62688438	0.648	NM_198723	TCEA2	transcription elongation factor A (SII), 2
chr21_-_27543445	0.647	NM_001136131	APP	amyloid beta (A4) precursor protein
chrX_-_119603068	0.646		LAMP2	lysosomal-associated membrane protein 2
chr17_+_42264300	0.645	NM_001076674 NM_024107	TMUB2	transmembrane and ubiquitin-like domain containing 2
chr15_-_90347534	0.640		ANPEP	alanyl (membrane) aminopeptidase
chr19_-_36246411	0.637		HSPB6	heat shock protein, alpha-crystallin-related, B6
chr4_+_88928797	0.636	NM_000297	PKD2	polycystic kidney disease 2 (autosomal dominant)
chr7_+_143078395	0.631		ZYX	zyxin
chr14_+_24867926	0.629	NM_025081	NYNRIN	NYN domain and retroviral integrase containing
chr21_-_46293561	0.627		PTTG1IP	pituitary tumor-transforming 1 interacting protein
chr21_-_46293598	0.627		PTTG1IP	pituitary tumor-transforming 1 interacting protein
chr17_-_40575117	0.627	NM_012232	PTRF	polymerase I and transcript release factor
chr21_+_35014624	0.625	NM_001001132 NM_003024	ITSN1	intersectin 1 (SH3 domain protein)
chr20_-_23066828	0.625	NM_012072	CD93	CD93 molecule
chr20_-_36793646	0.623	NM_004613 NM_198951	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr6_+_89791510	0.622		PNRC1	proline-rich nuclear receptor coactivator 1
chr17_+_42264573	0.622	NM_177441	TMUB2	transmembrane and ubiquitin-like domain containing 2
chr19_+_50016490	0.619		FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chr13_+_32605436	0.619	NM_023037	FRY	furry homolog (Drosophila)
chr7_+_143078457	0.618		ZYX	zyxin
chr19_-_49658645	0.609	NM_002152	HRC	histidine rich calcium binding protein
chr4_-_85887543	0.607	NM_014991	WDFY3	WD repeat and FYVE domain containing 3
chr1_-_95392449	0.605		CNN3	calponin 3, acidic
chr15_-_48937795	0.593	NM_000138	FBN1	fibrillin 1
chr11_-_27742224	0.591	NM_001143805 NM_001143806 NM_170732	BDNF	brain-derived neurotrophic factor
chr15_+_96876568	0.589	NM_001145157	NR2F2	nuclear receptor subfamily 2, group F, member 2
chr13_-_96705565	0.588	NM_020121	UGGT2	UDP-glucose glycoprotein glucosyltransferase 2
chr2_+_30369868	0.585		YPEL5	yippee-like 5 (Drosophila)
chr8_+_26371461	0.583	NM_001197293	DPYSL2	dihydropyrimidinase-like 2
chr15_-_48937068	0.582		FBN1	fibrillin 1
chr13_+_110959592	0.580	NM_001846	COL4A2	collagen, type IV, alpha 2
chr10_-_15413054	0.579	NM_001010924	FAM171A1	family with sequence similarity 171, member A1
chr1_+_19971865	0.577	NM_001204085	NBL1	neuroblastoma, suppression of tumorigenicity 1
chr10_-_33247131	0.576		ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr2_-_113191106	0.576	NM_001164463 NM_005054	RGPD8 RGPD5	RANBP2-like and GRIP domain containing 8 RANBP2-like and GRIP domain containing 5
chr1_+_86046434	0.569	NM_001554	CYR61	cysteine-rich, angiogenic inducer, 61
chr14_+_101193313	0.569		DLK1	delta-like 1 homolog (Drosophila)
chr19_+_50353942	0.568		PTOV1	prostate tumor overexpressed 1
chr14_+_101193190	0.568	NM_003836	DLK1	delta-like 1 homolog (Drosophila)
chr9_+_35792405	0.567	NM_003995	NPR2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr21_-_46293532	0.565		PTTG1IP	pituitary tumor-transforming 1 interacting protein
chr12_-_51420097	0.565	NM_000617 NM_001174126 NM_001174127 NM_001174128	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr9_-_116840545	0.564		AMBP	alpha-1-microglobulin/bikunin precursor
chr20_-_25566137	0.559	NM_025176	NINL	ninein-like
chr21_-_46293609	0.558	NM_004339	PTTG1IP	pituitary tumor-transforming 1 interacting protein
chr13_-_52980234	0.541		THSD1	thrombospondin, type I, domain containing 1
chr1_+_182992329	0.541	NM_002293	LAMC1	laminin, gamma 1 (formerly LAMB2)
chr3_-_55521567	0.538		WNT5A	wingless-type MMTV integration site family, member 5A
chr22_+_44319685	0.535		PNPLA3	patatin-like phospholipase domain containing 3
chr17_-_36105005	0.532	NM_000458 NM_001165923	HNF1B	HNF1 homeobox B
chr1_+_28919006	0.531	NM_001193532	RAB42	RAB42, member RAS oncogene family
chr20_+_62694456	0.529		TCEA2	transcription elongation factor A (SII), 2
chr1_-_33815411	0.528		PHC2	polyhomeotic homolog 2 (Drosophila)
chr6_-_46459010	0.528	NM_001251974	RCAN2	regulator of calcineurin 2
chrX_-_153640358	0.526	NM_001009932 NM_001009933 NM_001009934	DNASE1L1	deoxyribonuclease I-like 1
chr8_-_57906423	0.524	NM_017813	IMPAD1	inositol monophosphatase domain containing 1
chr5_+_52776408	0.520		FST	follistatin
chr3_+_50306578	0.516		SEMA3B	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr12_+_66218879	0.515		HMGA2	high mobility group AT-hook 2
chr17_+_42264582	0.514		TMUB2	transmembrane and ubiquitin-like domain containing 2
chr19_+_50016606	0.511		FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chr12_-_89746244	0.509	NM_001946 NM_022652	DUSP6	dual specificity phosphatase 6

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
10.66	2.67e-04	GO:0001568	blood vessel development
2.92	3.20e-04	GO:0048731	system development
9.94	4.56e-04	GO:0001944	vasculature development
3.54	4.89e-04	GO:0048513	organ development
2.21	6.71e-04	GO:0032501	multicellular organismal process
2.58	1.27e-03	GO:0007275	multicellular organismal development
7.04	1.56e-03	GO:0072358	cardiovascular system development
7.04	1.56e-03	GO:0072359	circulatory system development
2.45	1.58e-03	GO:0032502	developmental process
2.64	1.86e-03	GO:0048856	anatomical structure development
17.96	3.51e-03	GO:0030198	extracellular matrix organization
17.55	3.92e-03	GO:0031589	cell-substrate adhesion
4.84	4.02e-03	GO:0040011	locomotion
4.64	1.64e-02	GO:0009888	tissue development
3.48	1.78e-02	GO:0007399	nervous system development
4.58	1.81e-02	GO:0048699	generation of neurons
3.02	2.00e-02	GO:0030154	cell differentiation
3.43	2.08e-02	GO:0009653	anatomical structure morphogenesis
2.94	2.75e-02	GO:0048869	cellular developmental process
11.71	2.80e-02	GO:0043062	extracellular structure organization
4.31	3.02e-02	GO:0022008	neurogenesis
17.16	3.73e-02	GO:0030336	negative regulation of cell migration
17.16	3.73e-02	GO:2000146	negative regulation of cell motility
8.11	3.78e-02	GO:0030334	regulation of cell migration
5.42	3.83e-02	GO:0006928	cellular component movement
8.04	3.97e-02	GO:2000145	regulation of cell motility
16.05	4.85e-02	GO:0051271	negative regulation of cellular component movement
5.24	4.88e-02	GO:0009887	organ morphogenesis

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
5.18	1.02e-05	GO:0044421	extracellular region part
18.91	4.39e-05	GO:0044420	extracellular matrix part
3.49	2.27e-04	GO:0005576	extracellular region
8.36	2.54e-04	GO:0031012	extracellular matrix
5.13	3.50e-04	GO:0005615	extracellular space
8.84	7.79e-04	GO:0005578	proteinaceous extracellular matrix
21.30	2.42e-03	GO:0005604	basement membrane
28.07	1.12e-02	GO:0005581	collagen
56.11	3.90e-02	GO:0005583	fibrillar collagen

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
22.71	1.85e-04	GO:0005201	extracellular matrix structural constituent
19.93	3.50e-03	GO:0005178	integrin binding
10.81	6.92e-03	GO:0061134	peptidase regulator activity
7.34	1.11e-02	GO:0032403	protein complex binding
3.67	1.97e-02	GO:0005102	receptor binding
77.15	2.22e-02	GO:0008191	metalloendopeptidase inhibitor activity
77.15	2.22e-02	GO:0010576	metalloenzyme regulator activity
77.15	2.22e-02	GO:0048551	metalloenzyme inhibitor activity
12.24	2.34e-02	GO:0019838	growth factor binding
68.58	2.85e-02	GO:0003706	ligand-regulated transcription factor activity
10.94	3.59e-02	GO:0004866	endopeptidase inhibitor activity
10.75	3.84e-02	GO:0030414	peptidase inhibitor activity
10.48	4.23e-02	GO:0061135	endopeptidase regulator activity
56.11	4.33e-02	GO:0048407	platelet-derived growth factor binding